How does organellar pH affect brain function? 

Every organelles, e.g., endosomes, lysosomes, synaptosomes, etc, maintain specific luminal pH. But is this just "a profile" for various organelles, or does it have specific functions in different neuronal cells and glia, ultimately the brain? 

My previous work demonstrated that proton efflux from endolysosomes functions as a signaling cue to regulate endosomal maturation and membrane trafficking in neurons. We further showed that disruption of endolysosomal pH is sufficient to drive neurodevelopmental defects and neurodegeneration.

Building on these discoveries, our laboratory seeks to understand how the endolysosomal system orchestrates cellular communication and brain homeostasis. 

Our research is driven by biological questions rather than any single method or model. We choose the experimental approach that best addresses the problem, integrating molecular and cellular biology, advanced imaging, rat/mouse models, behavioral analyses, and systems-level approaches to uncover how organelle dysfunction disrupts brain function in development, aging, and neurodegenerative disease.