Endosome maturation is orchestrated by inside-out proton signaling through a Na+/H+ exchanger and pH-dependent Rab GTPase cycling. 
Lee Y, Ouyang Q, Ma L, Fleishman M, Riaz HA, Schmidt M, Dupree JL, Mondal A, Mohanty P, Mittal J, Beckstein O, Lambright DG, Morrow EM. Nature Communications. (2026) doi: 10.1038/s41467-026-72568-5. PMID: 42098086
 

Quantitative Measurement of Tau Aggregation in Genetically Modified Rats with Neurodegeneration.

Lee Y, Morrow EM. Methods Mol Biol. (2024) doi: 10.1007/978-1-0716-3662-6_21
 

Loss of endosomal exchanger NHE6 leads to pathological changes in tau in human neurons.

Fernandez MA, Bah F, Ma L, Lee Y, Schmidt M, Welch E, Morrow EM, Young-Pearse TL. Stem Cell Reports. (2022) doi: 10.1016/j.stemcr.2022.08.001. PMID: 36055242
 

Early lysosome defects precede neurodegeneration with amyloid-β and tau aggregation in NHE6-null rat brain.

Lee Y, Miller MR, Fernandez MA, Berg EL, Prada AM, Ouyang Q, Schmidt M, Silverman JL, Young-Pearse TL, Morrow EM. Brain. (2022) doi: 10.1093/brain/awab467. PMID: 34928329
 

TIA1 variant drives myodegeneration in multisystem proteinopathy with SQSTM1 mutations.

Lee Y, Jonson PH, Sarparanta J, Palmio J, Sarkar M, Vihola A, Evilä A, Suominen T, Penttilä S, Savarese M, Johari M, Minot MC, Hilton-Jones D, Maddison P, Chinnery P, Reimann J, Kornblum C, Kraya T, Zierz S, Sue C, Goebel H, Azfer A, Ralston SH, Hackman P, Bucelli RC, Taylor JP, Weihl CC*, Udd B*. J Clin Invest. (2018) doi: 10.1172/JCI97103. PMID: 29457785 *co-corresponding authors
 

Regulation of SQSTM1/p62 via UBA domain ubiquitination and its role in disease.

Lee Y, Weihl CC. Autophagy (2017) doi: 10.1080/15548627.2017.1339845. PMID: 28812433

Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination.

Lee Y, Chou TF, Pittman SK, Keith AL, Razani B, Weihl CC. Cell Rep. (2017) doi: 10.1016/j.celrep.2017.03.030.PMID: 28380357
 

Altered cofactor regulation with disease-associated p97/VCP mutations.

Zhang X, Gui L, Zhang X, Bulfer SL, Sanghez V, Wong DE, Lee Y, Lehmann L, Lee JS, Shih PY, Lin HJ, Iacovino M, Weihl CC, Arkin MR, Wang Y, Chou TF. Proc Natl Acad Sci U S A. (2015)  doi: 10.1073/pnas.1418820112. Epub 2015 Mar 16.PMID: 25775548
 

Targeted sequencing and identification of genetic variants in sporadic inclusion body myositis.

Weihl CC, Baloh RH, Lee Y, Chou TF, Pittman SK, Lopate G, Allred P, Jockel-Balsarotti J, Pestronk A, Harms MB. Neuromuscul Disord. (2015) doi: 10.1016/j.nmd.2014.12.009. Epub 2015 Jan 6.PMID: 25617006
 

A novel mutation in VCP causes Charcot-Marie-Tooth Type 2 disease.

Gonzalez MA, Feely SM, Speziani F, Strickland AV, Danzi M, Bacon C, Lee Y, Chou TF, Blanton SH, Weihl CC, Zuchner S, Shy ME. Brain. (2014) doi: 10.1093/brain/awu224. PMID: 25125609
 

Human placenta-derived mesenchymal stem cells promote hepatic regeneration in CCl4 -injured rat liver model via increased autophagic mechanism.

Jung J, Choi JH, Lee Y, Park JW, Oh IH, Hwang SG, Kim KS, Kim GJ. Stem Cells. (2013) doi: 10.1002/stem.1396. PMID: 23592412
 

Increased SCF/c-kit by hypoxia promotes autophagy of human placental chorionic plate-derived mesenchymal stem cells via regulating the phosphorylation of mTOR

Lee Y, Jung J, Cho KJ, Lee SK, Park JW, Oh IH, Kim GJ. J Cell Biochem. (2013) doi: 10.1002/jcb.24303 PMID: 22833529​